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Julie Muncy
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The first two official, non-production images of Star Trek: Discovery are out in the wild, and they showcase a new alien design as well as hint at a season that will begin, at least, with the meeting of the past and the present of Trek.

Both of these images come from Manu Atelier Navy Blue Fernweh Mini Suede backpack Excellent Online kLNTaf
, who’s doing a whole series of early looks at film and TV in advance of San Diego Comic-Con next week. The first, from the EW online portal, shows Michael Burnham (Sonequa Martin-Green) walking through a pair of doors on the USS Enterprise.

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According to EW’s caption, this is Burnham walking onto the bridge of the Enterprise, although the Trek experts at Trek Movie speculate, based on a production video from earlier in the spring, that it might actually be Burnham walking into a room labelled 3F, which they think might be Spock’s quarters.

The other image, from EW’s print edition, shows a new design for the Saurian race first showcased in Star Trek: The Motion Picture, in the form of a character named Linus, who looks to be a science officer.

Trek Movie also transcribes some quotes from Martin-Green from the print issue. In one, she reveals the Saurian as Linus, and says, “We’ve seen his species before, so I’m excited to see if [fans] can pinpoint just exactly where.” Before in Discovery? Commenters, get busy.

The other quote has to deal with the second season as a whole, about which Martin-Green says, “Beyond that, we’re really going to be digging into family.” She continues: “A lot of questions are going to be raised; some are going to be answered.”

While not revealing all that much, that quote, along with the images, suggest that blending the new take on Trek ’s past in Discovery with the history we already knew is going to be an important focus of this second season. Maybe we’ll actually see the present—er, past?—version of Spock!

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Julie Muncy

io9 Weekend Editor. Videogame writer at other places. Queer nerd girl.

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This article was updated on: 07/06/2018

Certain parts of Medicare may have late-enrollment penalties if you don’t sign up when you’re first eligible. These Medicare late-enrollment penalties may apply if you delay enrollment for Medicare Part A,Part B, and/orPart D.

Usually, you’re first eligible for Original Medicare, Part A and Part B, when you turn 65. You’ll get an Initial Enrollment Period that starts three months before you turn 65, includes the month of your 65th birthday, and ends three months later. Some people are eligible for Medicare before age 65 if they receive disability benefits for more than two years or have amyotrophic lateral sclerosis or end-stage renal disease.

For Medicare Part D (prescription drug coverage), generally you’re first eligible to enroll when you have Medicare Part A and/or Part B, and you live in the service area of a Medicare Part D Prescription Drug Plan. Most of the time, your Initial Enrollment Period (IEP) for Medicare Part D will take place at the same time as your Initial Enrollment Period for Original Medicare Part A and Part B. Medicare Part D is optional, but a late-enrollment penalty may apply if you decide to get this coverage after your IEP.

Late-enrollment penalties may apply when you enroll in Medicare Part A, Part B, or Part D after your Initial Enrollment Period. However, there are some situations where you can delay enrollment without facing a Medicare late-enrollment penalty.

Medicare Part A late-enrollment penalty

Most people get Medicare Part A premium free, as long as they’ve worked at least 10 years (40 quarters) and paid Medicare taxes during that time. If you don’t have enough work history, however, you may have to pay a premium for Medicare Part A.

If you pay a premium for Medicare Part A, make sure you sign up when you’re first eligible or this amount could be higher. The Medicare Part A late-enrollment penalty is a 10% higher premium for twice the number of years that you were eligible, but didn’t sign up for Medicare Part A. For example, let’s say you were eligible for Medicare Part A, but didn’t enroll for two years. When you enroll in Medicare Part A, you’ll have to pay a higher premium for four years (or twice the number of years that you were eligible for Part A, but went without it).

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Naïve T-injected animals exhibited significant changes to the intestinal mucosa, including epithelial hyperplasia, expansion of the proliferative zone, loss of differentiation, and increased immune infiltrate ( Missoni metallic sheen trousers Cheap Great Deals Outlet Amazing Price Cheap Finishline gpygb1K5
and S2 Fig ). The majority (18/20) of the naïve T cell-injected animals showed some degree of crypt hyperplasia and immune cell infiltration, which were highly correlated to one another and with the amount of weight lost ( Where To Buy Redemption polka dot sheer blouse Cheap Sale 100% Authentic Sale Websites Footaction Sale Online Fast Delivery Online 8KXbNUb
). The increased height of the colonic crypts was due to the dramatic increase in the number of epithelial cells per crypt ( S2 Fig ). Immunohistochemistry ( S2 Fig ) and immunophenotyping ( S3 Fig ) revealed that many immune cell types were present in increased numbers in the colons of animals with colitis. For example, in Rag1 null control animals, CD45+ cells made up only a small proportion of total colonic cells (0.1%–0.3%), and the majority of these cells were plasmacytoid dendritic cells (pDCs). In naïve T-injected animals, the percentage of CD45+ cells showed a strong correlation with crypt hyperplasia ( Fig 1B ), and this infiltrate was composed primarily of CD4+ T cells, macrophages, and neutrophils ( S3 Fig ), although the relative proportions of these cell types varied from animal to animal.

Fig 1. Phenotypic characterization of murine colitis.

(A) Representative histology of colons from control regulatory T cell (Treg)-injected animals and naïve T-injected animals with inflammation. The left panels show hematoxylin–eosin (HE)-stained colons; the center panels show immunohistochemistry for Ki-67, a marker of undifferentiated cells; and the right panels show immunohistochemistry for mucin-2, a marker for goblet cells. (B) Plot of average crypt height in distal colon versus the percentage of total CD45+ immune cells in the tissue, showing a strong positive relationship. R was determined by Spearman correlation. (C) Plot of average crypt height in distal colon versus weight loss score, showing a strong linear relationship. R was determined by Pearson correlation. (D) Plot of the percentage of total CD45+ immune cells in the colon versus weight loss score, showing a strong linear relationship. R was determined by Pearson correlation. (E) Scatter plots of crypt height profiles for the animals from panel A. Each dot represents a single crypt measurement and its location within the colon from distal to proximal colon. Focal and continuous inflammation classes were defined based on these profiles, with focal inflammation showing the variable phenotype (blue dots) and continuous inflammation showing consistent distal colon hyperplasia (red dots). The box at the bottom provides the immune infiltrate score at each location where crypts were measured, showing co-occurrence of hyperplasia and foci of immune infiltration. (F) Average crypt height profiles for each group, with the standard error about the mean indicated in shaded regions at points binned in 500-μm increments. N = 6, 7, and 8 for control, focal inflammation, and continuous inflammation, respectively. Underlying numerical values for panels B–F are provided in Buy Cheap Wide Range Of Discount Very Cheap Drome flared cuff skinny leather trousers Cheap Sale Comfortable Best Store To Get For Sale RvPrVnsa4
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'Price gouging' especially prevalent among for-profit hospitals that treat minorities, uninsured patients

Image credit : Spotmatik

By Vanessa McMains

/ Published May 30, 2017

In emergency rooms across the U.S., people are charged on average 340 percent more than what Medicare pays for services and treatments , with minorities and uninsured patients bearing the brunt of overcharges, a new study from the Johns Hopkins University School of Medicine has found.

The study, published online today in JAMA Internal Medicine , illustrates the need for greater transparency in hospital pricing, says senior investigator Discount Best Wholesale Furla Babylon purse Cheap Price For Sale View Sale Online Clearance Cheapest Price For Sale Official Site FISujyZv
, a professor of surgery at JHU's School of Medicine.

"There are massive disparities in service costs across emergency rooms, and that price gouging is the worst for the most vulnerable populations," Makary says. "Our study found that inequality is then further compounded on poor, minority groups, who are more likely to receive services from hospitals that charge the most."

For the study, researchers examined medical billing records dated in 2013 for 12,337 emergency medicine physicians in nearly 300 hospitals in all 50 states, then cross-referenced those records with the 2013 American Hospital Association database to determine the size, regional location, and other details of the emergency department, such as urban/rural status, teaching status, and for-profit status. They compared the costs billed to patients and the Medicare allowable amount—the sum of what Medicare pays for a service or procedure.

The relationship the researchers uncovered between the charges billed to patients and the Medicare allowable amount was known as the markup ratio. A markup ratio of 4.0, for example, means that for a service with a Medicare allowable amount of $100, the hospital charged patients $400—which would be 300 percent over the Medicare allowable amount.

Researchers found that emergency medicine physicians on average had a markup ratio of 4.4 compared to the Medicare allowable amount—resulting in 340 percent more in charges. Emergency departments that charged patients the most were more likely to be located in for-profit hospitals in the southeastern and Midwestern U.S. and serve populations of uninsured African-American and Hispanic patients. Wound closure services had the highest median markup ratio at 7.0, and interpreting head CT scans had the greatest in-hospital variation, with markup ratios ranging between 1.6 and 27 within a single hospital.

"This is a health care systems problem that requires state and federal legislation to protect patients," says Tim Xu, a fourth year medical student at JHU and the study's first author. "Patients really have no way of protecting themselves from these pricing practices."

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